An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids

J Pediatr. 2017 Feb;181:286-288. doi: 10.1016/j.jpeds.2016.11.004. Epub 2016 Nov 23.

Abstract

We report a retrospective case series of 19 infants exposed to both opioids and gabapentin prenatally. We describe a unique behavioral phenotype in 15 of these infants and report a treatment strategy.

Keywords: NAS; co-exposure; gabapentin; neonatology; opioids; withdrawal.

MeSH terms

  • Amines / adverse effects*
  • Amines / therapeutic use
  • Analgesics, Opioid / adverse effects*
  • Analgesics, Opioid / therapeutic use
  • Cyclohexanecarboxylic Acids / adverse effects*
  • Cyclohexanecarboxylic Acids / therapeutic use
  • Female
  • Gabapentin
  • Humans
  • Infant
  • Infant, Newborn
  • Methadone / therapeutic use*
  • Neonatal Abstinence Syndrome / drug therapy*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / epidemiology*
  • Retrospective Studies
  • gamma-Aminobutyric Acid / adverse effects*
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Amines
  • Analgesics, Opioid
  • Cyclohexanecarboxylic Acids
  • gamma-Aminobutyric Acid
  • Gabapentin
  • Methadone