Adult Patients With Bronchiectasis: A First Look at the US Bronchiectasis Research Registry

Chest. 2017 May;151(5):982-992. doi: 10.1016/j.chest.2016.10.055. Epub 2016 Nov 23.


Objectives: We sought to describe the characteristics of adult patients with bronchiectasis enrolled in the US Bronchiectasis Research Registry (BRR).

Methods: The BRR is a database of patients with non-cystic-fibrosis bronchiectasis (NCFB) enrolled at 13 sites in the United States. Baseline demographic, spirometric, imaging, microbiological, and therapeutic data were entered into a central Internet-based database. Patients were subsequently analyzed by the presence of NTM.

Results: We enrolled 1,826 patients between 2008 and 2014. Patients were predominantly women (79%), white (89%), and never smokers (60%), with a mean age of 64 ± 14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation for entry into the BRR. Patients with NTM were older, predominantly women, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux disease (GERD) was more common in those with NTM, whereas asthma, primary immunodeficiency, and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. Patients with NTM were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were cultured less commonly in patients with NTM. Bronchial hygiene measures were used more often in those with NTM, whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM.

Conclusions: Adult patients with bronchiectasis enrolled in the US BRR are described, with differences noted in demographic, radiographic, microbiological, and treatment variables based on stratification of the presence of NTM.

Keywords: Pseudomonas; airways; bronchiectasis; nontuberculous mycobacteria; registry.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Asthma / epidemiology
  • Biomedical Research
  • Black or African American / statistics & numerical data
  • Bronchiectasis / epidemiology*
  • Bronchiectasis / microbiology
  • Bronchiectasis / physiopathology
  • Comorbidity
  • Ethnicity / statistics & numerical data
  • Female
  • Forced Expiratory Volume
  • Gastroesophageal Reflux / epidemiology
  • Hispanic or Latino / statistics & numerical data
  • Humans
  • Immunologic Deficiency Syndromes / epidemiology*
  • Insurance, Health
  • Kartagener Syndrome / epidemiology*
  • Male
  • Middle Aged
  • Mycobacterium Infections, Nontuberculous / epidemiology*
  • Mycobacterium Infections, Nontuberculous / microbiology
  • Nontuberculous Mycobacteria
  • Otitis / epidemiology
  • Pseudomonas
  • Pseudomonas Infections / epidemiology
  • Registries*
  • Rhinitis / epidemiology
  • Sinusitis / epidemiology
  • Smoking / epidemiology
  • Spirometry
  • Staphylococcal Infections / epidemiology
  • Staphylococcus aureus
  • Tomography, X-Ray Computed
  • United States / epidemiology
  • Vital Capacity
  • White People / statistics & numerical data