HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients

Arthritis Rheum. 1989 Sep;32(9):1135-41. doi: 10.1002/anr.1780320912.


We examined the distribution of non-B27 alleles of the HLA-B locus among B27+ patients with ankylosing spondylitis (AS), to detect any additional HLA-B locus allele(s) that may act in conjunction with B27 to increase susceptibility to AS. HLA-Bw60 (or B40 when the Bw60,61 split of B40 was not typed for) was shown to be increased among B27+ AS patients in each of 5 independent data sets. This increase was statistically significant in 4 of the 5 data sets studied, and the overall significance was P less than 0.00001. Susceptibility to AS in B27+ individuals was further increased by a factor of approximately 3 when Bw60 was also present. The distribution of HLA-A alleles on the B27-bearing haplotypes in AS patients was not significantly different from that in normal controls. On the other hand, the distribution of HLA-A alleles on Bw60-bearing haplotypes was significantly different from the distribution of A alleles on Bw60 haplotypes in the general population (P less than 0.0005). Bw60 was not increased in B27- patients with AS. A dominant mode of inheritance generally fits AS; however, our sib pair analysis indicates that the B27,Bw60 disease subgroup follows a more recessive mode of inheritance.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Canada
  • Disease Susceptibility
  • Genotype
  • HLA-B Antigens / genetics*
  • HLA-B27 Antigen
  • Haplotypes
  • Humans
  • Netherlands
  • Norway
  • Phenotype
  • Spondylitis, Ankylosing / genetics*
  • Switzerland
  • United States


  • HLA-B Antigens
  • HLA-B27 Antigen
  • HLA-B60 antigen