Intraocular non-Hodgkin's lymphoma treated with systemic and intrathecal chemotherapy and radiotherapy. A case report and review of the literature

Graefes Arch Clin Exp Ophthalmol. 1989;227(4):355-9. doi: 10.1007/BF02169412.


A case of therapy-resistant bilateral intermediate uveitis is presented. Vitreous biopsy and lumbar puncture resulted in the diagnosis of high-grade malignant non-Hodgkin's lymphoma (NHL). Because chemotherapy and radiotherapy continue to yield better results in the treatment of NHL and a cure can be reached in a large group of patients with high-grade malignant NHL, early diagnosis is very important. We therefore recommend early vitreous biopsy in persistent, bilateral, granulomatous intermediate uveitis, especially in older patients. Our patient achieved a complete remission (follow-up period at the time of writing, 18 months after the beginning of polychemotherapy and radiotherapy). The chemotherapy modalities are briefly discussed.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols*
  • Biopsy
  • Cyclophosphamide / therapeutic use
  • Cytarabine / therapeutic use*
  • Doxorubicin / therapeutic use
  • Eye Neoplasms / diagnosis*
  • Female
  • Humans
  • Injections, Spinal
  • Leucovorin / therapeutic use
  • Lymphoma, Non-Hodgkin / drug therapy*
  • Lymphoma, Non-Hodgkin / radiotherapy
  • Methotrexate / therapeutic use
  • Middle Aged
  • Prednisone / therapeutic use
  • Retinal Diseases / drug therapy
  • Retinal Diseases / pathology*
  • Uveitis / complications
  • Vincristine / therapeutic use
  • Visual Acuity
  • Vitreous Body / pathology


  • Cytarabine
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Leucovorin
  • Prednisone
  • Methotrexate

Supplementary concepts

  • MTX-CHOP protocol