Three new drimane sesquiterpenoids from cultures of the fungus Penicillium sp

J Asian Nat Prod Res. 2017 Aug;19(8):780-785. doi: 10.1080/10286020.2016.1261830. Epub 2016 Nov 28.

Abstract

Three new drimane sesquiterpenoids, 12-hydroxyalbrassitriol (1), drim-8(12)-en-6β,7α, 9α,11-tetraol (2), and drim-68(12)-dien-9α,11-diol (3), along with one known analog albrassitriol (4), were isolated from cultures of the tin mine tailings-associated fungus Penicillium sp. The new structures were determined on the basis of extensive spectroscopic analyses. All compounds were tested for their cytotoxicities against five human cancer cell lines.

Keywords: Penicillium sp.; cytotoxicities; drimane sesquiterpenoids; fungus.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • China
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Penicillium / chemistry*
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • 12-hydroxyalbrassitriol
  • Antineoplastic Agents
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • drimane