A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl

Leuk Lymphoma. 2017 Mar;58(3):718-721. doi: 10.1080/10428194.2016.1207765. Epub 2016 Nov 28.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles
  • Biomarkers
  • Bone Marrow / pathology
  • Clonal Evolution / genetics*
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA Methylation
  • DNA Methyltransferase 3A
  • DNA Mutational Analysis
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / genetics*
  • Leukocyte Count
  • Mutation*
  • Myelodysplastic Syndromes / diagnosis
  • Myelodysplastic Syndromes / genetics*
  • Precancerous Conditions / genetics*

Substances

  • Biomarkers
  • DNMT3A protein, human
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A