A role for interleukin 1 in the in vivo actions of tumor necrosis factor

Lymphokine Res. 1989 Fall;8(3):269-74.


We have observed a marked species specificity in the in vivo antitumor, shock-inducing and Interleukin-6 (IL-6)-inducing activities of human recombinant TNF (hrTNF) versus murine rTNF (mrTNF) in mouse models. We also have observed that this species specificity can be abolished when synergistic factors are co-administered. We now present data showing that the profiles of induced IL-6 and TNF after lethal and non-lethal doses of endotoxin are different. These results are discussed in the context of a model of dual signalling for the induction of the major post-endotoxin phenomena that takes into consideration the involvement of Interleukin-1 (IL-1) in the in vivo actions of TNF.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Endotoxins / toxicity
  • Humans
  • Interleukin-1 / physiology*
  • Interleukin-6
  • Interleukins / biosynthesis
  • Kinetics
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Species Specificity
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Tumor Necrosis Factor-alpha / pharmacology*


  • Endotoxins
  • Interleukin-1
  • Interleukin-6
  • Interleukins
  • Tumor Necrosis Factor-alpha