Eczema and Urticaria as Manifestations of Undiagnosed and Rare Diseases

Molly J Youssef; Yvonne E Chiu

doi:10.1016/j.pcl.2016.08.004

Eczema and Urticaria as Manifestations of Undiagnosed and Rare Diseases

Pediatr Clin North Am. 2017 Feb;64(1):39-56. doi: 10.1016/j.pcl.2016.08.004.

Authors

Molly J Youssef¹, Yvonne E Chiu²

Affiliations

¹ Department of Dermatology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
² Section of Pediatric Dermatology, Department of Dermatology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: ychiu@mcw.edu.

PMID: 27894451
DOI: 10.1016/j.pcl.2016.08.004

Abstract

Eczema and urticaria are common disorders encountered in pediatric patients, but they may occasionally be the presenting complaint in a child with an underlying rare disease. Immunodeficiency syndromes should be suspected when eczema is associated with neonatal onset, recurrent infections, chronic lymphadenopathy, or failure to thrive. Nutritional deficiencies and mycosis fungoides are in the differential diagnosis for a child with a recalcitrant eczematous eruption. Autoinflammatory syndromes should be suspected in a child with chronic urticaria, fever, and other systemic signs of inflammation. Although these disorders are rare, early recognition allows for appropriate treatment and decreased morbidity for the child.

Keywords: Autoinflammatory syndromes; Eczema; Immunodeficiency syndromes; Mycosis fungoides; Nutritional deficiencies; Urticaria.

Publication types

Review

MeSH terms

Child
Child Nutrition Disorders / diagnosis
Diagnosis, Differential
Eczema / diagnosis*
Hereditary Autoinflammatory Diseases / diagnosis
Humans
Immunologic Deficiency Syndromes / diagnosis
Mycosis Fungoides / diagnosis
Rare Diseases / diagnosis*
Urticaria / diagnosis*