Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals

Biomed Res Int. 2016;2016:8274504. doi: 10.1155/2016/8274504. Epub 2016 Nov 8.

Abstract

Exposure to environmental and occupational toxicants is responsible for adverse effects on human health. Chelation therapy is the only procedure able to remove toxic metals from human organs and tissue, aiming to treat damage related to acute and/or chronic intoxication. The present review focuses on the most recent evidence of the successful use of the chelating agent ethylenediaminetetraacetic acid (EDTA). Assessment of toxic-metal presence in humans, as well as the rationale of EDTA therapy in cardiovascular and neurodegenerative diseases, is reported.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Chelating Agents / chemistry*
  • Edetic Acid / chemistry*
  • Environmental Pollutants / chemistry
  • Female
  • Geography
  • Humans
  • Inflammation
  • Iron / chemistry
  • Male
  • Metals / chemistry*
  • Middle Aged
  • Neurodegenerative Diseases / etiology
  • Occupational Exposure
  • Pregnancy
  • Pregnancy Complications
  • Rats
  • Rats, Wistar
  • Thalassemia / blood

Substances

  • Antioxidants
  • Chelating Agents
  • Environmental Pollutants
  • Metals
  • Edetic Acid
  • Iron