Broad-spectrum antiviral properties of andrographolide

Arch Virol. 2017 Mar;162(3):611-623. doi: 10.1007/s00705-016-3166-3. Epub 2016 Nov 28.


Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as 'creat'. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress, Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). All these properties of andrographolide form the foundation for the use of this miraculous compound to restrain virus replication and virus-induced pathogenesis. The present article covers antiviral properties of andrographolide in variety of viral infections, with the hope of developing of a new highly potent antiviral drug with multiple effects.

Publication types

  • Review

MeSH terms

  • Andrographis / chemistry*
  • Animals
  • Antiviral Agents / pharmacology*
  • Diterpenes / pharmacology*
  • Humans
  • Oxidative Stress
  • Plant Extracts / pharmacology*
  • Virus Diseases / drug therapy
  • Virus Diseases / virology*
  • Viruses / drug effects*


  • Antiviral Agents
  • Diterpenes
  • Plant Extracts
  • andrographolide