The effect of erythropoietin on uterus inflammation during ischemia reperfusion injury in rats

Ceska Gynekol. 2016 Fall;81(5):342-348.


Objective: This experiment evaluated the influence of erythropoietin (Epo) in an animal model of uterine ischemia reperfusion using the quoting established protocol.

Design: The effects of erythropoietin treatment were evaluated by mean uterus inflammation (UI) lesions. UI lesions were determined at the 60th reperfusion min (for groups A and C) and at the 120th reperfusion min (for groups B and D). Groups A and B received no drugs, whereas rats from groups C and D were administered with erythropoietin.

Methods: 40 rats of mean mass 247.7 g were employed for the study.

Results: Epo administration non-significantly decreased the UI scores [without lesions] by 0.1 [-0.6244129 - 0.4244129] (p = 0.6294)). Reperfusion time kept non-significantly increased the UI scores by [without lesions] 0.15 [-0.60230385 - 0.50230385] (p = 0.5782). Together, Epo administration combined with reperfusion time non-significantly decreased the UI scores by [without lesions] 0.0727273 [-0.3886782 - 0.2432236] (p = 0.6439).

Conclusions: Epo administration whether it interacted or not with reperfusion time non-significantly short-term decreased the UI lesions scores. Perhaps, a longer study time than two hours or a higher Epo dose may provide more significant effects.

Keywords: erythropoietin; ischemia; uterus inflammation reperfusion..

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Disease Models, Animal
  • Erythropoietin / pharmacology*
  • Female
  • Inflammation / drug therapy*
  • Rats, Wistar
  • Reperfusion Injury / prevention & control*
  • Uterus / blood supply*


  • Antioxidants
  • Erythropoietin