A novel and efficient Fe-catalyzed direct C-H amination (NH2 ) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.
Keywords: C−H functionalization; amination; iron; new reagents; radical.
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