Association between aerobic exercise training effects of serum adropin level, arterial stiffness, and adiposity in obese elderly adults

Appl Physiol Nutr Metab. 2017 Jan;42(1):8-14. doi: 10.1139/apnm-2016-0310. Epub 2016 Sep 13.


Serum levels of adropin, which enhances endothelial cell release of nitric oxide (NO), are lower in obese patients. Although habitual aerobic exercise reduces arterial stiffness and adiposity, the relationship between these effects and circulating levels of adropin remains unclear. The purpose of this study was to determine if serum adropin level is associated with the effects of aerobic exercise training on arterial stiffness and adiposity in obese adults. In Experiment 1, we examined whether serum adropin levels are associated with cardiorespiratory fitness, carotid β-stiffness, plasma nitrite/nitrate (NOx) level, and abdominal visceral fat in 27 normal, 20 overweight, and 25 obese adults (age, 41-79 years). In Experiment 2, we examined the effects of an 8-week aerobic exercise training program on the relationship between serum adropin level and arterial stiffness or adiposity in 13 obese adults (age, 54-76 years). Serum adropin levels in normal, overweight, and obese adults negatively correlated with carotid β-stiffness and abdominal visceral fat, and positively correlated with plasma NOx level and cardiorespiratory fitness. After the 8-week exercise program, serum adropin levels in obese adults were elevated, and correlated with training-induced changes in carotid β-stiffness (r = -0.573, P < 0.05), plasma NOx level (r = 0.671, P < 0.05), and abdominal visceral fat (r = -0.585, P < 0.05). These findings suggest that the exercise training-induced increase in serum adropin may be related to the training effects of arterial stiffness and adiposity in obese adults.

Keywords: abdominal visceral fat; adropin; adropine; carotid β-stiffness; entraînement physique; exercise training; gras viscéral dans l’abdomen; nitric oxide; obesity; obésité; oxyde nitrique; rigidité-β de l’artère carotide.

MeSH terms

  • Adiposity*
  • Adult
  • Aged
  • Blood Proteins
  • Body Mass Index
  • Cardiorespiratory Fitness*
  • Carotid Artery, Common / diagnostic imaging
  • Carotid Artery, Common / physiopathology
  • Cross-Sectional Studies
  • Exercise*
  • Female
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Middle Aged
  • Nitrates / blood
  • Nitric Oxide / blood
  • Nitrites / blood
  • Obesity / blood
  • Obesity / metabolism
  • Obesity / physiopathology
  • Obesity / therapy*
  • Overweight / blood
  • Overweight / metabolism
  • Overweight / physiopathology
  • Overweight / therapy*
  • Oxygen Consumption
  • Peptides / blood*
  • Physical Exertion
  • Physical Fitness
  • Vascular Stiffness*


  • Blood Proteins
  • Enho protein, human
  • Intercellular Signaling Peptides and Proteins
  • Nitrates
  • Nitrites
  • Peptides
  • Nitric Oxide