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. 2017 Jan 4;45(D1):D115-D118.
doi: 10.1093/nar/gkw1052. Epub 2016 Nov 28.

RAID v2.0: An Updated Resource of RNA-associated Interactions Across Organisms

Free PMC article

RAID v2.0: An Updated Resource of RNA-associated Interactions Across Organisms

Ying Yi et al. Nucleic Acids Res. .
Free PMC article


With the development of biotechnologies and computational prediction algorithms, the number of experimental and computational prediction RNA-associated interactions has grown rapidly in recent years. However, diverse RNA-associated interactions are scattered over a wide variety of resources and organisms, whereas a fully comprehensive view of diverse RNA-associated interactions is still not available for any species. Hence, we have updated the RAID database to version 2.0 (RAID v2.0, by integrating experimental and computational prediction interactions from manually reading literature and other database resources under one common framework. The new developments in RAID v2.0 include (i) over 850-fold RNA-associated interactions, an enhancement compared to the previous version; (ii) numerous resources integrated with experimental or computational prediction evidence for each RNA-associated interaction; (iii) a reliability assessment for each RNA-associated interaction based on an integrative confidence score; and (iv) an increase of species coverage to 60. Consequently, RAID v2.0 recruits more than 5.27 million RNA-associated interactions, including more than 4 million RNA-RNA interactions and more than 1.2 million RNA-protein interactions, referring to nearly 130 000 RNA/protein symbols across 60 species.


Figure 1.
Figure 1.
Flowchart of database construction and the statistics of RNA categories and interactions. (A) The overview of the RAID v2.0 database; (B) The percentage of diverse RNA categories in RAID v2.0 database; (C) The number of RNA–RNA/RNA–protein interactions for diverse RNA categories in RAID v2.0 database, the height of histogram transformed by log10.

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