The Effect of Topical Use of Petroselinum Crispum (Parsley) Versus That of Hydroquinone Cream on Reduction of Epidermal Melasma: A Randomized Clinical Trial

Holist Nurs Pract. 2017 Jan/Feb;31(1):16-20. doi: 10.1097/HNP.0000000000000186.


Melasma disfigures the skin and thus influences people's self-image and self-concept. Therefore, melasma influences emotional and psychosocial health in addition to physical health. This clinical trial was performed to assess the effect of the topical use of Petroselinum crispum (parsley) on reduction of the severity of epidermal melasma.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dermatologic Agents / chemistry
  • Dermatologic Agents / therapeutic use*
  • Female
  • Humans
  • Hydroquinones / therapeutic use*
  • Melanosis / drug therapy*
  • Melanosis / pathology
  • Middle Aged
  • Petroselinum / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use*
  • Treatment Outcome
  • Young Adult


  • Dermatologic Agents
  • Hydroquinones
  • Plant Extracts
  • hydroquinone