Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome

Diabetes. 2017 Feb;66(2):418-425. doi: 10.2337/db16-0680. Epub 2016 Nov 30.


Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes in the gut microbiome were characterized by a decreased relative abundance of Turicibacteraceae, Moryella, Lachnospiraceae, and Akkermansia and an increased relative abundance of Bacteroides and Parabacteroides Moreover, fecal transplantation from healthy resveratrol-fed donor mice is sufficient to improve glucose homeostasis in obese mice, suggesting that the resveratrol-mediated changes in the gut microbiome may play an important role in the mechanism of action of resveratrol.

MeSH terms

  • Animals
  • Bacteroides
  • Blood Glucose / drug effects*
  • Blood Glucose / metabolism
  • Chromatography, Liquid
  • Fecal Microbiota Transplantation
  • Gastrointestinal Microbiome / drug effects*
  • Gastrointestinal Microbiome / genetics
  • Glucose / metabolism
  • Glucose Tolerance Test
  • Homeostasis / drug effects
  • Male
  • Mice
  • Mice, Obese
  • Obesity / metabolism*
  • Obesity / microbiology
  • Resveratrol
  • Stilbenes / pharmacology*
  • Tandem Mass Spectrometry


  • Blood Glucose
  • Stilbenes
  • Glucose
  • Resveratrol