Interferon alfa-2b in the management of recurrent conjunctival papillomatosis

Indian J Ophthalmol. 2016 Oct;64(10):778-780. doi: 10.4103/0301-4738.195013.


A 2-year-old boy presented with a recurrent strawberry-like reddish mass arising from the left caruncular region for 8 months. An incisional biopsy was performed elsewhere 2 months earlier, followed by an increase in size of mass, significant epiphora, and intermittent bleeding. On examination, exuberant exophytic gelatinous mass with multifocal origin was observed arising from inferior forniceal conjunctiva and caruncle. Clinical differential of multifocal conjunctival papilloma was kept, and topical interferon alfa-2b (INFα-2b) was started. No clinical reduction in mass or symptomatology was observed over 6 weeks. Excision biopsy with cryotherapy and subconjunctival injection of INFα-2b was performed over all foci. Conjunctival papilloma was confirmed on histopathology, and topical INFα-2b was continued in postoperative period for 3 months. At 14 months of follow-up, no recurrence, epiphora, or bleeding was noticed. We advocate a possible role of local INF therapy in managing and preventing recurrences of conjunctival papillomatosis.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Biopsy
  • Child, Preschool
  • Conjunctiva / pathology*
  • Conjunctival Neoplasms / diagnosis
  • Conjunctival Neoplasms / drug therapy*
  • Follow-Up Studies
  • Humans
  • Immunologic Factors / administration & dosage
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage*
  • Male
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / drug therapy*
  • Papilloma / diagnosis
  • Papilloma / drug therapy*
  • Recombinant Proteins / administration & dosage


  • Immunologic Factors
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins