Stem cells and interspecies chimaeras

Nature. 2016 Dec 1;540(7631):51-59. doi: 10.1038/nature20573.


Chimaeras are both monsters of the ancient imagination and a long-established research tool. Recent advances, particularly those dealing with the identification and generation of various kinds of stem cells, have broadened the repertoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding fundamental biology as well as potential clinical applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Blastocyst / cytology
  • Cell Lineage
  • Chimera* / embryology
  • Drug Evaluation, Preclinical
  • Humans
  • Species Specificity
  • Stem Cell Research / ethics
  • Stem Cell Research / legislation & jurisprudence
  • Stem Cells / cytology*