Bacterial E3 ligase effectors exploit host ubiquitin systems

Curr Opin Microbiol. 2017 Feb;35:16-22. doi: 10.1016/j.mib.2016.11.001. Epub 2016 Nov 28.

Abstract

Ubiquitination is a crucial post-translational protein modification involved in regulation of various cellular processes in eukaryotes. In particular, ubiquitination is involved in multiple aspects of bacterial infection and host defense mechanisms. In parallel with the identification of ubiquitination as a component of host defense systems, recently accumulated evidence shows that many bacterial pathogens exploit host ubiquitin systems to achieve successful infection. Here, we highlight the strategies by which bacteria subvert host ubiquitin systems by mimicking E3 ubiquitin ligase activity.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria / enzymology*
  • Bacteria / metabolism
  • Bacteria / pathogenicity*
  • Bacterial Infections / metabolism
  • Bacterial Infections / microbiology*
  • Host-Pathogen Interactions*
  • Humans
  • Type III Secretion Systems / metabolism
  • Type IV Secretion Systems / metabolism
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*
  • Ubiquitination*
  • Virulence Factors / metabolism

Substances

  • Type III Secretion Systems
  • Type IV Secretion Systems
  • Virulence Factors
  • Ubiquitin-Protein Ligases