Genetic variants in the ZNF208 gene are associated with esophageal cancer in a Chinese Han population

Oncotarget. 2016 Dec 27;7(52):86829-86835. doi: 10.18632/oncotarget.13468.


Previous studies showed an association between the ZNF208 gene and gastric cancer. In this study, we investigated the association between single nucleotide polymorphisms (SNPs) in ZNF208 and the risk of esophageal cancer in a Chinese Han population. We conducted a case-control study that included 386 cases and 495 controls. Five SNPs were selected from previous genome-wide association studies and genotyped using the Sequenom MassARRAY platform. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals after adjustment for age and gender. Logistic regressionl analysis showed that two SNPs (rs8103163 and rs7248488) were associated with an increased risk of esophageal cancer under different inheritance models after Bonferroni correction. Haplotype analysis suggested that the four variants comprised one block, and that the Grs2188972Crs2188971Crs8103163Crs7248488 haplotype was significantly correlated with an increased risk of esophageal cancer. Our data indicate that variants in ZNF208 are contribute to the susceptibility to esophageal cancer in a Chinese Han population.

Keywords: ZNF208; association study; esophageal cancer; single nucleotide polymorphisms (SNPs).

MeSH terms

  • Adult
  • Aged
  • Asians / genetics
  • Case-Control Studies
  • China
  • DNA-Binding Proteins
  • Esophageal Neoplasms / ethnology
  • Esophageal Neoplasms / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / ethnology
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Haplotypes
  • Humans
  • Kruppel-Like Transcription Factors / genetics*
  • Linkage Disequilibrium
  • Logistic Models
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Transcription Factors


  • DNA-Binding Proteins
  • Kruppel-Like Transcription Factors
  • Transcription Factors
  • ZKSCAN5 protein, human