Antibiotic Exposure and Risk for Death or Bronchopulmonary Dysplasia in Very Low Birth Weight Infants

Joseph B Cantey; Landon W Huffman; Abirami Subramanian; Anderson S Marshall; A Rebecca Ballard; Cassandra Lefevre; Malvika Sagar; Jessica E Pruszynski; Lea H Mallett

doi:10.1016/j.jpeds.2016.11.002

Antibiotic Exposure and Risk for Death or Bronchopulmonary Dysplasia in Very Low Birth Weight Infants

J Pediatr. 2017 Feb:181:289-293.e1. doi: 10.1016/j.jpeds.2016.11.002. Epub 2016 Nov 28.

Authors

Joseph B Cantey¹, Landon W Huffman², Abirami Subramanian³, Anderson S Marshall³, A Rebecca Ballard², Cassandra Lefevre², Malvika Sagar², Jessica E Pruszynski⁴, Lea H Mallett²

Affiliations

¹ Department of Pediatrics, Texas A&M Health Science Center, Baylor Scott & White Health, Temple, TX. Electronic address: jcantey@sw.org.
² Department of Pediatrics, Texas A&M Health Science Center, Baylor Scott & White Health, Temple, TX.
³ Texas A&M Health Science Center College of Medicine, College Station, TX.
⁴ Department of Biostatistics, Baylor Scott & White Health, Temple, TX.

PMID: 27908652
DOI: 10.1016/j.jpeds.2016.11.002

Abstract

We assessed the association between antibiotic exposure in the first 2 weeks of life and development of bronchopulmonary dysplasia in a cohort of very low birth weight infants. After controlling for the severity of illness, each additional day of antibiotic therapy was associated with both an increased risk for and severity of bronchopulmonary dysplasia.

Keywords: Neonatal intensive care unit; Neonate.

MeSH terms

Anti-Bacterial Agents / adverse effects*
Bronchopulmonary Dysplasia / etiology*
Bronchopulmonary Dysplasia / mortality
Cohort Studies
Female
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Male
Retrospective Studies
Risk Factors

Substances

Anti-Bacterial Agents