Is Daily Low-Dose Aspirin Safe to Take Following Laparoscopic Roux-en-Y Gastric Bypass for Obesity Surgery?

Obes Surg. 2017 May;27(5):1261-1265. doi: 10.1007/s11695-016-2462-z.


Background: Laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery is a safe and effective procedure for patients with severe obesity. One potential complication of LRYGB is the development of marginal ulcers (MUs). Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to significantly increase the likelihood of developing marginal ulcers after surgery. However, the risk associated with low-dose aspirin consumption is not well defined. We examined the impact of daily low-dose aspirin (81 mg) on the development of marginal ulcers following LRYGB.

Methods: A retrospective cohort design studied patients undergoing LRYGB surgery, between January 2009 and January 2013, at a single, high-volume bariatric center in Ontario, Canada. The marginal ulcer rate of patients taking low-dose aspirin after surgery was compared to that of the control patients who did not take any NSAID. Diagnosis of MU was confirmed by upper endoscopy in patients presenting with symptoms and a history indicative of marginal ulceration. A chi-square test of independence was performed to examine the difference in marginal ulcer rates.

Results: A total of 1016 patients underwent LRYGB. Patients taking aspirin were more likely to be male, older, and have diabetes than patients not taking NSAIDs. Of the 1016 patients, 145 (14.3%) took low-dose aspirin following LRYGB and the rest did not (n = 871, 85.7%). The incidence of marginal ulceration was not significantly different between the two treatment groups (12/145, 8.3% versus 90/871, 10.3%; p = 0.45).

Conclusions: Patients treated with LRYGB at our institution were not at increased risk of marginal ulcer formation when taking low-dose aspirin after surgery.

Keywords: LRYGB; Low-dose aspirin; Marginal ulcer.

MeSH terms

  • Adult
  • Aspirin / administration & dosage*
  • Female
  • Gastric Bypass / adverse effects*
  • Humans
  • Laparoscopy
  • Male
  • Middle Aged
  • Obesity, Morbid / surgery*
  • Peptic Ulcer / chemically induced
  • Peptic Ulcer / etiology*
  • Platelet Aggregation Inhibitors / administration & dosage*
  • Retrospective Studies


  • Platelet Aggregation Inhibitors
  • Aspirin