Recommendations for a nomenclature system for reporting methylation aberrations in imprinted domains

Epigenetics. 2018;13(2):117-121. doi: 10.1080/15592294.2016.1264561. Epub 2018 Jan 25.

Abstract

The analysis of DNA methylation has become routine in the pipeline for diagnosis of imprinting disorders, with many publications reporting aberrant methylation associated with imprinted differentially methylated regions (DMRs). However, comparisons between these studies are routinely hampered by the lack of consistency in reporting sites of methylation evaluated. To avoid confusion surrounding nomenclature, special care is needed to communicate results accurately, especially between scientists and other health care professionals. Within the European Network for Human Congenital Imprinting Disorders we have discussed these issues and designed a nomenclature for naming imprinted DMRs as well as for reporting methylation values. We apply these recommendations for imprinted DMRs that are commonly assayed in clinical laboratories and show how they support standardized database submission. The recommendations are in line with existing recommendations, most importantly the Human Genome Variation Society nomenclature, and should facilitate accurate reporting and data exchange among laboratories and thereby help to avoid future confusion.

Keywords: Imprinting; imprinting disorders; methylation; nomenclature.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Methylation*
  • Epigenomics / standards*
  • Genomic Imprinting*
  • Humans
  • Polymorphism, Genetic
  • Practice Guidelines as Topic
  • Terminology as Topic*

Grant support

This work was supported by the European COST action under grant number BM1208, the Bundesministerium für Bildung und Forschung (BMBF) under grant number 01GM1513A, B, C and D, the Spanish Ministerio de Educación y Competitividad (MINECO) under grant number BFU2014–53,093 co-funded with the European Union Regional Development Fund (FEDER), the Wellcome Trust under grant number WT200990/Z/16/Z and by the European Molecular Biology Laboratory.