Nucleotide modifications in messenger RNA and their role in development and disease

Biochem Soc Trans. 2016 Oct 15;44(5):1385-1393. doi: 10.1042/BST20160110.

Abstract

Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.

Keywords: RNA editing; epitranscriptome; mRNA methylation.

Publication types

  • Review

MeSH terms

  • Animals
  • Arabidopsis / genetics
  • Caenorhabditis elegans / genetics
  • Disease / genetics*
  • Drosophila melanogaster / genetics
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Mutation
  • Nucleotides / genetics*
  • RNA Editing*
  • RNA, Messenger / genetics*
  • Saccharomyces cerevisiae / genetics

Substances

  • Nucleotides
  • RNA, Messenger