Nucleotide modifications in messenger RNA and their role in development and disease

Biochem Soc Trans. 2016 Oct 15;44(5):1385-1393. doi: 10.1042/BST20160110.


Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.

Keywords: RNA editing; epitranscriptome; mRNA methylation.

Publication types

  • Review

MeSH terms

  • Animals
  • Arabidopsis / genetics
  • Caenorhabditis elegans / genetics
  • Disease / genetics*
  • Drosophila melanogaster / genetics
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Mutation
  • Nucleotides / genetics*
  • RNA Editing*
  • RNA, Messenger / genetics*
  • Saccharomyces cerevisiae / genetics


  • Nucleotides
  • RNA, Messenger