Control of HIV-1 gene expression by SR proteins

Biochem Soc Trans. 2016 Oct 15;44(5):1417-1425. doi: 10.1042/BST20160113.


Cellular proteins are required for all steps of human immunodeficiency virus type 1 (HIV-1) gene expression including transcription, splicing, 3'-end formation/polyadenylation, nuclear export and translation. SR proteins are a family of cellular RNA-binding proteins that regulate and functionally integrate multiple steps of gene expression. Specific SR proteins are best characterised for regulating HIV-1 RNA splicing by binding specific locations in the viral RNA, though recently they have also been shown to control transcription, 3'-end formation, and translation. Due to their importance in regulating HIV-1 gene expression, SR proteins and their regulatory factors are potential antiviral drug targets.

Keywords: HIV; RNA metabolism; SR proteins; alternative splicing; eukaryotic gene expression.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions / genetics
  • Gene Expression Regulation, Viral*
  • HIV-1 / genetics*
  • HIV-1 / metabolism
  • Humans
  • Models, Genetic
  • Protein Binding
  • RNA Splicing
  • RNA, Viral / genetics*
  • RNA, Viral / metabolism
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism
  • Virion / genetics
  • Virion / metabolism


  • 3' Untranslated Regions
  • RNA, Viral
  • RNA-Binding Proteins