Hirschsprung's disease and Ondine's curse: further evidence for a distinct syndrome

Clin Genet. 1989 Sep;36(3):200-3. doi: 10.1111/j.1399-0004.1989.tb03189.x.


Although Hirschsprung's disease is a relatively common congenital malformation, with an estimated incidence of about 1:5000, Primary Central Hypoventilation Syndrome (Ondine's curse) is exceedingly rare, with about 50 reported cases. We describe a patient with total colonic aganglionosis occurring together with failure of automatic control of respiration, specific facial dysmorphology and characteristic CT scan changes to substantiate further the syndromic nature of this association.

Publication types

  • Case Reports

MeSH terms

  • Facial Bones / abnormalities*
  • Female
  • Hirschsprung Disease / complications*
  • Hirschsprung Disease / genetics
  • Humans
  • Infant, Newborn
  • Skull / abnormalities*
  • Sleep Apnea Syndromes / complications*
  • Sleep Apnea Syndromes / genetics
  • Syndrome