Primary central nervous system lymphoma

Tracy T Batchelor

doi:10.1182/asheducation-2016.1.379

Primary central nervous system lymphoma

Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):379-385. doi: 10.1182/asheducation-2016.1.379.

Author

Tracy T Batchelor¹

Affiliation

¹ Departments of Neurology and Radiation Oncology, Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA.

Abstract

Primary central nervous system lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma (NHL) confined to the brain, leptomeninges, eyes, or spinal cord. The majority of PCNSL cases occur in the immunocompetent host, the focus of this review. The prognosis of PCNSL is inferior to that of other NHL subtypes including other organ-specific subtypes of extranodal NHL. The 5- and 10-year survival proportions for PCNSL are 29.3% and 21.6%, respectively. The diagnosis and management of PCNSL differs from that of other primary brain cancers and NHL in other parts of the body.

Publication types

Review

MeSH terms

Central Nervous System Neoplasms* / diagnosis
Central Nervous System Neoplasms* / mortality
Central Nervous System Neoplasms* / therapy
Disease-Free Survival
Humans
Lymphoma, Non-Hodgkin* / diagnosis
Lymphoma, Non-Hodgkin* / mortality
Lymphoma, Non-Hodgkin* / therapy
Survival Rate
Time Factors