Cortical stimulation parameters for functional mapping

Seizure. 2017 Feb;45:36-41. doi: 10.1016/j.seizure.2016.11.015. Epub 2016 Nov 23.

Abstract

Purpose: There is significant variation in how patients respond to cortical electrical stimulation. It has been hypothesized that individual demographic and pathologic factors, such as age, sex, disease duration, and MRI findings, may explain this discrepancy. The purpose of our study is to identify specific patient characteristics and their effect on cortical stimulation, and discover the extent of variation in behavioral responses that exists among patients with epilepsy.

Method: We retrospectively analyzed data from 92 patients with medically intractable epilepsy who had extra-operative cortical electrical stimulation. Mapping records were evaluated and information gathered about demographic data, as well as the thresholds of stimulation for motor, sensory, speech, and other responses; typical seizure behavior; and the induction of afterdischarges.

Results: Ninety-two patient cortical stimulation mapping reports were analyzed. The average of the minimum thresholds for motor response was 4.15mA±2.67. The average of the minimum thresholds for sensory response was 3.50mA±2.15. The average of the minimum thresholds for speech response was 4.48mA±2.42. The average of the minimum thresholds for afterdischarge was 4.33mA±2.37. Most striking were the degree of variability and wide range of thresholds seen between patients and within the different regions of the same patient.

Conclusion: Wide ranges of thresholds exist for the different responses between patients and within different regions of the same patient. With multivariate analysis in these series, no clinical or demographic factors predicted physiological response or afterdischarge threshold levels.

Keywords: Afterdischarge; Cortex functional mapping; Perirolandic epilepsy; Sensory and motor cortex; Stimulation threshold.

MeSH terms

  • Adolescent
  • Adult
  • Brain Mapping*
  • Brain Waves / physiology*
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / physiopathology*
  • Child
  • Child, Preschool
  • Electric Stimulation / methods*
  • Electroencephalography
  • Epilepsy / diagnostic imaging
  • Epilepsy / pathology*
  • Epilepsy / physiopathology
  • Epilepsy / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neuroimaging
  • Retrospective Studies
  • Sensory Thresholds / physiology
  • Young Adult