Case series: Antidepressant effects of low-affinity and low-trapping NMDA receptor antagonists did not predict response to ketamine in seven subjects

J Psychiatr Res. 2017 Mar;86:55-57. doi: 10.1016/j.jpsychires.2016.10.023. Epub 2016 Nov 22.
No abstract available

Keywords: Antidepressant; Depression; Glutamate; Ketamine; Memantine; NMDA receptor antagonist.

Publication types

  • Letter
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adamantane / analogs & derivatives
  • Adamantane / therapeutic use
  • Adult
  • Antidepressive Agents / therapeutic use*
  • Depression / drug therapy*
  • Excitatory Amino Acid Antagonists / therapeutic use*
  • Female
  • Humans
  • Ketamine / therapeutic use*
  • Male
  • Memantine / therapeutic use
  • Middle Aged
  • Niacinamide / analogs & derivatives
  • Niacinamide / therapeutic use
  • Predictive Value of Tests
  • Psychiatric Status Rating Scales
  • Receptors, N-Methyl-D-Aspartate / metabolism*
  • Treatment Outcome

Substances

  • AZD6925
  • Antidepressive Agents
  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate
  • Niacinamide
  • Ketamine
  • Adamantane
  • Memantine

Associated data

  • ClinicalTrials.gov/NCT00986479
  • ClinicalTrials.gov/NCT00040261
  • ClinicalTrials.gov/NCT00088699