The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns

Pestic Biochem Physiol. 2016 Nov;134:49-54. doi: 10.1016/j.pestbp.2016.04.007. Epub 2016 Apr 19.


Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined. Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities in pregnant rats and their newborns. Pregnant rats showed cellular oxidative stress and altered oxidant-antioxidant status when treated by the insecticide and these disturbances were also seen in their newborns. In conclusion, low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. Alpha-cypermethrin should be used with caution especially during pregnancy.

Keywords: Alpha-cypermethrin; Metabolism; Offspring; Oxidative stress; Pregnancy; Rat.

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Animals, Newborn
  • Aspartate Aminotransferases / blood
  • Blood Glucose / analysis
  • Body Weight / drug effects
  • Female
  • Glutathione / metabolism
  • Insecticides / toxicity*
  • Lipids / blood
  • Liver / drug effects
  • Liver / metabolism
  • Malondialdehyde / metabolism
  • Maternal-Fetal Exchange
  • Metabolic Diseases / blood
  • Metabolic Diseases / chemically induced*
  • Metabolic Diseases / metabolism
  • Oxidation-Reduction
  • Oxidative Stress / drug effects*
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Pyrethrins / toxicity*
  • Rats
  • Rats, Wistar


  • Blood Glucose
  • Insecticides
  • Lipids
  • Pyrethrins
  • cypermethrin
  • Malondialdehyde
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Glutathione