Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

Crit Care Med. 1989 Oct;17(10):975-8. doi: 10.1097/00003246-198910000-00001.

Abstract

In a study of serum levels of tumor necrosis factor (TNF alpha) and interleukin-1 beta (IL-1 beta) in patients developing sepsis in the ICU, high TNF alpha levels were found in patients with septic shock. Normal values are 75 +/- 15 pg/ml; in these patients, TNF alpha serum level ranged from 100 to 5000 pg/ml with a mean of 701 +/- 339 pg/ml and a median of 250 pg/ml. There was a correlation between TNF alpha level and sepsis severity score as well as with mortality. In contrast, IL-1 beta serum levels were only slightly increased and were not correlated with severity or mortality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Interleukin-1 / blood*
  • Male
  • Middle Aged
  • Sepsis / blood*
  • Shock, Septic / blood*
  • Shock, Septic / mortality
  • Tumor Necrosis Factor-alpha / analysis*

Substances

  • Interleukin-1
  • Tumor Necrosis Factor-alpha