Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Dec 5;17(1):163.
doi: 10.1186/s12931-016-0479-4.

'The Microbiome and the Pathophysiology of Asthma'

Affiliations
Free PMC article
Review

'The Microbiome and the Pathophysiology of Asthma'

Ashley Sullivan et al. Respir Res. .
Free PMC article

Abstract

Asthma is a chronic respiratory disease whose prevalence is increasing in the western world. Recently research has begun to focus on the role the microbiome plays in asthma pathogenesis in the hope of further understanding this respiratory disorder. Considered sterile until recently, the lungs have revealed themselves to contain a unique microbiota. A shift towards molecular methods for the quantification and sequencing of microbial DNA has revealed that the airways harbour a unique microbiota with apparent, reproducible differences present between healthy and diseased lungs. There is a hope that in classifying the microbial load of the asthmatic airway an insight may be afforded as to the possible role pulmonary microbes may have in propagating an asthmatic airway response. This could potentially pave the way for new therapeutic strategies for the treatment of chronic lung conditions such as asthma.

Keywords: Asthma; Epithelium; Host; Hygiene hypothesis; Inflammation; Medicine; Microbe dialogue; Microbiology; Translational research.

Figures

Fig. 1
Fig. 1
Factors influencing the lung microbiome. Schematic illustrating the complex factors affecting the lung microbiome in Asthma. The lung microenvironment selects for specific microbes which change in Asthma due to environmental factors, infection and treatment options which modulate the inflammatory cascade at the epithelial interface and the corresponding microbiome. Asthmatics display a changed microbiome with increased lung microbes such as Haemophilus, Neisseria, Moraxella, Staphylococcus, and Streptoccoccus with reduced Veillonella, Faecalibacterium, Lachospira and Rothia sp

Similar articles

See all similar articles

Cited by 9 articles

See all "Cited by" articles

References

    1. Kim HY, DeKruyff RH, Umetsu DT. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol. 2010;11(7):577–584. doi: 10.1038/ni.1892. - DOI - PMC - PubMed
    1. Hilty M, et al. Disordered microbial communities in asthmatic airways. PLoS One. 2010;5:1. doi: 10.1371/journal.pone.0008578. - DOI - PMC - PubMed
    1. Edwards MR, et al. The microbiology of asthma. Nat Rev Micro. 2012;10(7):459–471. - PubMed
    1. Burney P, Jarvis D, Perez-Padilla R. The global burden of chronic respiratory disease in adults. Int J Tuberc Lung Dis. 2015;19(1):10–20. doi: 10.5588/ijtld.14.0446. - DOI - PubMed
    1. Umetsu DT, et al. Asthma: an epidemic of dysregulated immunity. Nat Immunol. 2002;3(8):715–720. doi: 10.1038/ni0802-715. - DOI - PubMed

Publication types

Substances

Feedback