Implementing the Risk of Ovarian Malignancy Algorithm Adding Obesity as a Predictive Factor

Emanuela Anastasi; Danila Capoccia; Teresa Granato; Gianfranco Silecchia; Mario Rizzello; Maria Grazia Porpora; Luigi Frati; Antonio Angeloni; Frida Leonetti

doi:10.21873/anticanres.11240

Implementing the Risk of Ovarian Malignancy Algorithm Adding Obesity as a Predictive Factor

Anticancer Res. 2016 Dec;36(12):6425-6429. doi: 10.21873/anticanres.11240.

Authors

Emanuela Anastasi¹, Danila Capoccia², Teresa Granato³, Gianfranco Silecchia⁴, Mario Rizzello⁴, Maria Grazia Porpora⁵, Luigi Frati⁶, Antonio Angeloni⁶, Frida Leonetti²

Affiliations

¹ Department of Molecular Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy emanuela.anastasi@uniroma1.it.
² Department of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
³ CNR-IBPM, National Research Council, Rome, Italy.
⁴ Department of Medico-Surgical Sciences and Biotechnologies, Bariatric Center of Excellence IFSO EU, Sapienza University of Rome, Latina, Italy.
⁵ Department of Gynaecology, Obstetrics and Urology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
⁶ Department of Molecular Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

PMID: 27919964
DOI: 10.21873/anticanres.11240

Abstract

Aim: To evaluate whether obesity represents a risk factor for the onset of ovarian cancer.

Patients and methods: One hundred and sixty-three patients with a body mass index (BMI) >30 kg/m² (group 1) and 130 women with a BMI of <25 kg/m² (group 2) were included in the study.

Results: A Risk of Ovarian Malignancy Algorithm (ROMA) index above the cut-off (>13%) was found in 24.5% of group 1 patients, whereas a high ROMA score was identified in 5.3% of group 2 women. During the study, 13 out of 40 group 1 patients with ROMA >13% were deemed eligible for bariatric surgery. After bariatric surgery and decrease of BMI, eight out of these 13 obese women had a ROMA index <13%.

Conclusion: The ROMA index may function as a simple test able to screen obese women at risk of developing ovarian cancer.

Keywords: CA125; HE4; Obesity; ROMA index; bariatric surgery; insulin; ovarian cancer.

MeSH terms

Adult
Algorithms*
Body Mass Index
Female
Humans
Middle Aged
Obesity / complications*
Ovarian Neoplasms / complications
Ovarian Neoplasms / epidemiology*
Risk Factors
Young Adult