Prognostic Factors After Whole-brain Radiotherapy Alone for Brain Metastases from Malignant Melanoma

Anticancer Res. 2016 Dec;36(12):6637-6640. doi: 10.21873/anticanres.11271.

Abstract

Background/aim: Many patients with brain metastases from melanoma receive whole-brain radiotherapy (WBRT). WBRT-regimens must consider the patient's prognosis in order to deliver the best therapy.

Patients and methods: Seven factors were correlated to intracerebral control and survival after WBRT alone in 92 patients with melanoma: WBRT regimen, age at WBRT, gender, Karnofsky performance score (KPS), number of brain lesions, number of extracranial metastatic sites, and time from melanoma diagnosis to WBRT.

Results: On univariate analyses, KPS ≥80 (p=0.075) showed a trend towards improved intracerebral control. Greater WBRT dose (p=0.029), age ≤60 years (p=0.002), KPS ≥80 (p<0.001) and no extracranial site (p=0.008) were positively correlated with survival. On multivariate analyses, KPS (hazard ratio=2.11, 95% confidence interval=1.28-3.47; p=0.003) and number of extracranial metastatic sites (hazard ratio=1.27, 95% confidence interval=1.02-1.56; p=0.030) maintained significance regarding survival.

Conclusion: The study identified predictors of survival for patients with melanoma receiving WBRT for brain metastases that can contribute to selection of individualized therapies.

Keywords: Malignant melanoma; brain metastases; prognoses; treatment results; whole-brain radiotherapy.

MeSH terms

  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / secondary*
  • Female
  • Humans
  • Male
  • Melanoma / pathology*
  • Middle Aged
  • Prognosis