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. 2016 Dec 6;188(17-18):E537.

doi: 10.1503/cmaj.160357. Epub 2016 Nov 14.

Flumazenil in benzodiazepine overdose

Howard An¹, Jesse Godwin²

Affiliations

Affiliations

¹ Divisions of Emergency Medicine (Godwin) and Clinical Pharmacology and Toxicology (An, Godwin), Department of Medicine, University of Toronto; Ontario Poison Centre (An, Godwin), Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ont. howard.an@gmail.com.
² Divisions of Emergency Medicine (Godwin) and Clinical Pharmacology and Toxicology (An, Godwin), Department of Medicine, University of Toronto; Ontario Poison Centre (An, Godwin), Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ont.

PMID: 27920113
PMCID: PMC5135539
DOI: 10.1503/cmaj.160357

Flumazenil in benzodiazepine overdose

Howard An et al. CMAJ. 2016.

. 2016 Dec 6;188(17-18):E537.

doi: 10.1503/cmaj.160357. Epub 2016 Nov 14.

Authors

Howard An¹, Jesse Godwin²

Affiliations

¹ Divisions of Emergency Medicine (Godwin) and Clinical Pharmacology and Toxicology (An, Godwin), Department of Medicine, University of Toronto; Ontario Poison Centre (An, Godwin), Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ont. howard.an@gmail.com.
² Divisions of Emergency Medicine (Godwin) and Clinical Pharmacology and Toxicology (An, Godwin), Department of Medicine, University of Toronto; Ontario Poison Centre (An, Godwin), Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ont.

PMID: 27920113
PMCID: PMC5135539
DOI: 10.1503/cmaj.160357

No abstract available

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Comment in

Zopiclone overdose and flumazenil rescue.
Cimolai N. Cimolai N. CMAJ. 2017 Apr 24;189(16):E613. doi: 10.1503/cmaj.732933. CMAJ. 2017. PMID: 28438958 Free PMC article. No abstract available.

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References

1. Buckley NA, McManus PR. Changes in fatalities due to overdose of anxiolytic and sedative drugs in the UK (1983–1999). Drug Saf 2004;27:135–41. - PubMed
1. Penninga EI, Graudal N, Ladekarl MB, et al. Adverse events associated with flumazenil treatment for the management of suspected benzodiazepine intoxication: a systematic review with meta-analyses of randomised trials. Basic Clin Pharmacol Toxicol 2016;118:37–44. - PubMed
1. Sivilotti MLA. Flumazenil, naloxone and the ‘coma cocktail’.Br J Clin Pharmacol 2016;81:428–36. - PMC - PubMed
1. Jackson BF, Beck LA, Losek JD. Successful flumazenil reversal of paradoxical reaction to midazolam in a child. J Emerg Med 2015;48:e67–72. - PubMed
1. Anexate [package insert]. Basel (Switzerland): Hoffman–La Roche; 2008.

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