Improved Detection of Minimal Residual Disease by 11C-Methionine PET/CT in a Young Patient With Unusual Extramedullary Presentation of Recurrent Multiple Myeloma

Clin Nucl Med. 2017 Feb;42(2):e130-e134. doi: 10.1097/RLU.0000000000001462.

Abstract

Extramedullary relapse of multiple myeloma (MM) is uncommon. A 40-year-old woman with history of MM underwent PET/CT using C-methionine (C-MET) after the detection of a vulvar lesion on MRI, biopsy proven to be extramedullary relapse of MM. The vulvar lesion was negative at the F-FDG PET/CT but showed high uptake of C-MET; focal uptake of both F-FDG and C-MET was shown within the muscles of the left leg, histologically confirmed as extramedullary relapse of MM. F-FDG PET/CT performed after chemotherapy showed no uptake in both sites, whereas posttreatment C-MET PET/CT showed persistence of residual uptake within the vulvar lesion.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carbon Radioisotopes
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Methionine
  • Multiple Myeloma / diagnostic imaging*
  • Multiple Myeloma / pathology
  • Muscle Neoplasms / diagnostic imaging*
  • Muscle Neoplasms / secondary
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Positron Emission Tomography Computed Tomography*
  • Radiopharmaceuticals

Substances

  • Carbon Radioisotopes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Methionine