Modulation of brain PUFA content in different experimental models of mice

Prostaglandins Leukot Essent Fatty Acids. 2016 Nov:114:1-10. doi: 10.1016/j.plefa.2016.09.003. Epub 2016 Sep 30.


The relative amounts of arachidonic acid (AA) and docosahexaenoic acid (DHA) govern the different functions of the brain. Their brain levels depend on structures considered, on fatty acid dietary supply and the age of animals. To have a better overview of the different models available in the literature we here compared the brain fatty acid composition in various mice models (C57BL/6J, CD1, Fat-1, SAMP8 mice) fed with different n-3 PUFA diets (deficient, balanced, enriched) in adults and aged animals. Our results demonstrated that brain AA and DHA content is 1) structure-dependent; 2) strain-specific; 3) differently affected by dietary approaches when compared to genetic model of PUFA modulation; 4) different in n-3 PUFA deficient aged C57BL6/J when compared to SAMP8 mouse model of aging. From these experiments, we highlight the difficulty to compare results obtained in different mouse models, different strains, different brain regions and different ages.

Keywords: Aging; Arachidonic acid (AA); Brain regions; Docosahexaenoic acid (DHA); Fat-1 mice; N-3 PUFA; SAMP8 mice.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Arachidonic Acid / chemistry*
  • Brain Chemistry*
  • Brain Stem / chemistry
  • Cerebellum / chemistry
  • Cerebral Cortex / chemistry
  • Dietary Fats, Unsaturated / administration & dosage*
  • Docosahexaenoic Acids / chemistry*
  • Female
  • Hippocampus / chemistry
  • Hypothalamus / chemistry
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Models, Theoretical
  • Prefrontal Cortex / chemistry


  • Dietary Fats, Unsaturated
  • Docosahexaenoic Acids
  • Arachidonic Acid