What's the Key to Unlocking the Proteasome's Gate?

Structure. 2016 Dec 6;24(12):2037-2038. doi: 10.1016/j.str.2016.11.011.


In this issue of Structure, Bolten et al. (2016) describe the organization of the mycobacterial proteasome in complex with the ATP-independent bacterial proteasome activator (Bpa, PafE). They confirm several activation motifs employed by archaea and eukaryotes and highlight differences that pose Bpa as a novel architectural class of proteasome activators.

Publication types

  • Comment

MeSH terms

  • Proteasome Endopeptidase Complex / chemistry*


  • Proteasome Endopeptidase Complex