Physical exercise increases natural cellular-mediated tumor cytotoxicity in elderly women

Gerontology. 1989;35(2-3):66-71. doi: 10.1159/000213001.


The influence of acute treadmill exercise on natural killer (NK) cell tumor cytotoxicity in vitro was studied in elderly women after participation in a program of physical exercise training (PET) (n = 7) or after participation in a paralleling nonexercise control (NEC) condition (n = 7). The two study groups were equated (p greater than 0.05) according to age, percent total body fat, functional status as measured by multi-inventory ranking, and exercise capacity. After the experimental period, the PET subjects had a greater basal level of NK activity than the NEC subjects (PET 38.2 percent specific lysis, %SL, vs. NEC 28.8 %SL; p less than 0.05). Both groups experienced an increase in NK activity after acute treadmill exercise (PET 38.2-57.4 %SL, p less than 0.01; NEC 28.8-37.8 %SL, p less than 0.05), but the increase in the PET subjects was significantly (p less than 0.05) greater than that observed in the NEC subjects. We conclude that natural cellular-mediated tumor cytotoxicity is increased in response to acute exercise and long-term PET in elderly women.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Activities of Daily Living
  • Aged
  • Aging / immunology*
  • Body Composition
  • Cytotoxicity Tests, Immunologic
  • Cytotoxicity, Immunologic / immunology*
  • Exercise / physiology*
  • Exercise Test
  • Female
  • Humans
  • Killer Cells, Natural / immunology*
  • Physical Education and Training
  • Random Allocation