Rice Bran Extract Reduces the Risk of Atherosclerosis in Post-Menopausal Vietnamese Women

J Nutr Sci Vitaminol (Tokyo). 2016;62(5):295-302. doi: 10.3177/jnsv.62.295.

Abstract

We investigated whether pre-germinated brown rice bran extract containing acylated steryl glucosides (PSG) reduces the risk of atherosclerosis in post-menopausal Vietnamese women. A total of 60 post-menopausal Vietnamese women (45-65 y old) with high LDL cholesterol levels (over 140 mg/dL) were randomly divided into PSG (n=30) and placebo (n=30) groups. The subjects in the PSG group were assigned a daily intake of 6 capsules containing 50 mg PSG, and the subjects in the placebo group were assigned a daily intake of 6 capsules containing corn oil for 6 mo. Before baseline and after month 2, month 4, and month 6 of the intervention, we conducted anthropometric measurements, blood biochemical examinations, a nutrition survey, and physical activity, flow-mediated dilation (FMD), and cardio-ankle vascular index (CAVI) measurements. Serum LDL cholesterol concentrations were significantly reduced from 163.6±25.3 (mg/dL) to 135.9±26.8 (mg/dL) compared to the placebo group (p<0.001). FMD values of the placebo group were significantly reduced from 6.6±5.1 (%) to 4.7±2.6 (%) compared to the PSG group (p<0.05). Tumor necrosis factor (TNF)-α concentrations in the PSG group were significantly reduced from 19.8±11 (pg/mL) to 10.6±5.5 (pg/mL) compared to the placebo group (p<0.05). The findings suggest that PSG may improve LDL cholesterol, TNF-α levels, and FMD values. PSG might be considered in reducing the risk of atherosclerosis in post-menopausal Vietnamese women with high LDL cholesterol.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiponectin / blood
  • Aged
  • Asian Continental Ancestry Group
  • Atherosclerosis / blood
  • Atherosclerosis / drug therapy*
  • Body Mass Index
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Dietary Fiber / pharmacology*
  • Dose-Response Relationship, Drug
  • Exercise
  • Female
  • Humans
  • Middle Aged
  • Nutrition Surveys
  • Oryza / chemistry*
  • Plant Extracts / pharmacology*
  • Postmenopause
  • Risk Factors
  • Single-Blind Method
  • Triglycerides / blood
  • Tumor Necrosis Factor-alpha / blood
  • Vietnam

Substances

  • Adiponectin
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Dietary Fiber
  • Plant Extracts
  • Triglycerides
  • Tumor Necrosis Factor-alpha