Aim: IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC).
Materials & methods: IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method.
Results: The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC. Significantly increased PTC risk was also associated with rs17855750 GT and GT/GG genotypes. Combined genotypes of rs153109 AG/GG and rs17855750 GT/GG increased the risk of PTC (p < 0.05).
Conclusion: These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.
Keywords: IL-27; papillary thyroid carcinoma; risk; rs153109; rs17855750; single nucleotide polymorphism.