Not all chromosome imbalance resulting from the 11q;22q translocation is due to 3:1 segregation in first meiosis

D H Lockwood; A Farrier; F Hecht; J Allanson

doi:10.1007/BF00285174

Not all chromosome imbalance resulting from the 11q;22q translocation is due to 3:1 segregation in first meiosis

Hum Genet. 1989 Oct;83(3):287-8. doi: 10.1007/BF00285174.

Authors

D H Lockwood¹, A Farrier, F Hecht, J Allanson

Affiliation

¹ Genetics Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.

PMID: 2793173
DOI: 10.1007/BF00285174

Abstract

The constitutional translocation between chromosomes 11 and 22 [t(11;22)(q23.3;q11.2)] is one of the best known rearrangements in the human genome. Hitherto only one type of unbalanced karyotype, namely 47,XX or XY, +der(22) t(11;22)(q23.3;q11.2) was found among offspring of the translocation carriers. This result is the product of a 3:1 segregation at meiosis. We report an alternative unbalanced karyotype. The proband's karyotype is 47,XY,t(11;22)(q23.3;q11.2), +der(22)t(11;22)(q23.3;q11.2)pat. This finding cannot be due to nondisjunction in first meiosis of the translocation carrier.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Chromosome Banding
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 22*
Humans
Karyotyping
Meiosis*
Translocation, Genetic*

Grants and funding

CA-41124/CA/NCI NIH HHS/United States