The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology

Nikolaos Armakolas; Athanasios Armakolas; Athanasios Antonopoulos; Andreas Dimakakos; Martha Stathaki; Michael Koutsilieris

doi:10.1016/j.critrevonc.2016.11.004

The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology

Crit Rev Oncol Hematol. 2016 Dec:108:137-145. doi: 10.1016/j.critrevonc.2016.11.004. Epub 2016 Nov 15.

Authors

Nikolaos Armakolas¹, Athanasios Armakolas², Athanasios Antonopoulos³, Andreas Dimakakos⁴, Martha Stathaki⁵, Michael Koutsilieris⁶

Affiliations

¹ Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece; Third orthopaedic clinic, KAT General Hospital, Kifisia, Attiki, Greece. Electronic address: narmakolas@gmail.com.
² Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: aarmakol@med.uoa.gr.
³ Third orthopaedic clinic, KAT General Hospital, Kifisia, Attiki, Greece. Electronic address: thanosarmakolas@yahoo.com.
⁴ Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: dhmakak@med.uoa.gr.
⁵ Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: stathakimg@yahoo.gr.
⁶ Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: mkoutsil@med.uoa.gr.

PMID: 27931832
DOI: 10.1016/j.critrevonc.2016.11.004

Abstract

Growth hormone (GH) regulated mainly liver-produced insulin-like growth factor 1 (IGF-1) is a key molecule in embryonic & post embryonic development that is also involved in cancer biology. Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target.

Keywords: Bone; Ec peptide; IGF-1; IGF-1Ec; IGF-1R; Muscle repair; Osteosarcoma.

Publication types

Review

MeSH terms

Animals
Bone Neoplasms / genetics
Bone Neoplasms / metabolism*
Bone Neoplasms / physiopathology
Humans
Insulin-Like Growth Factor I / genetics
Insulin-Like Growth Factor I / metabolism*
Osteosarcoma / genetics
Osteosarcoma / metabolism*
Osteosarcoma / physiopathology
Protein Isoforms / genetics
Protein Isoforms / metabolism

Substances

IGF1 protein, human
Protein Isoforms
Insulin-Like Growth Factor I