Prognostic Value of Modified Banff Score in the Evolution of Renal Function

Transplant Proc. 2016 Nov;48(9):2903-2905. doi: 10.1016/j.transproceed.2016.09.013.

Abstract

Background: Some lesions not included in the Banff classification, such as inflammation in the scarred areas and total inflammation, have been described to have prognostic value in the evaluation of graft biopsies. Our aim was to reassess kidney graft biopsies and study the impact of histopathologic lesions, both those graded in the Banff classification and those related to inflammation, on the graft function and evolution.

Methods: We selected 20 biopsies exhibiting chronic pathology without a specific phenotype, and we reevaluated them with the use of a modified Banff score.

Results: We found statistically significant association between the presence of total inflammation (P = .048; P = .038), the presence of inflammation in scared area (P = .037; P = .018), and creatinine at the time of renal biopsy and 1 year after the renal biopsy, respectively.

Conclusions: Our results suggest that the presence of both inflammation in the scarred areas and total inflammation are related to renal function at the time of the biopsy and to renal function 1 year after the biopsy.

MeSH terms

  • Biopsy
  • Chronic Disease
  • Cicatrix / pathology
  • Creatinine / metabolism
  • Female
  • Graft Rejection / pathology
  • Humans
  • Kidney / pathology*
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Nephrectomy / methods
  • Nephritis / pathology
  • Nephritis / physiopathology
  • Organ Dysfunction Scores
  • Prognosis
  • Transplants / pathology*
  • Transplants / physiopathology

Substances

  • Creatinine