Exosomes: What Do We Love So Much About Them?

Circ Res. 2016 Dec 9;119(12):1280-1282. doi: 10.1161/CIRCRESAHA.116.309942.


Exosomes, once thought to be biomarkers of a diseased state are now thought to be biologically active and some of the paracrine effects of stem cell therapy. While there is much excitement around their actions, there is also a growing need to better understand the role of cell source, exosome content, and exosome targeting in a quantitative manner. Better understanding of these variables and others, in a reproducible and comprehensive approach, could better inform future therapy.

Keywords: biomarkers; cardiovascular system; exosome; microRNA; systems biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Exosomes / physiology*
  • Exosomes / transplantation*
  • Humans
  • Love
  • MicroRNAs / physiology
  • MicroRNAs / therapeutic use
  • Paracrine Communication / physiology*
  • Stem Cell Transplantation / methods
  • Stem Cell Transplantation / trends


  • MicroRNAs