Chemical Methods for Probing Virus-Host Proteomic Interactions

ACS Infect Dis. 2016 Nov 11;2(11):773-786. doi: 10.1021/acsinfecdis.6b00084. Epub 2016 Jun 29.


Interactions between host and pathogen proteins constitute an important aspect of both infectivity and the host immune response. Different viruses have evolved complex mechanisms to hijack host-cell machinery and metabolic pathways to redirect resources and energy flow toward viral propagation. These interactions are often critical to the virus, and thus understanding these interactions at a molecular level gives rise to opportunities to develop novel antiviral strategies for therapeutic intervention. This review summarizes current advances in chemoproteomic methods for studying these molecular altercations between different viruses and their hosts.

Keywords: activity-based protein profiling; chemoproteomics; protein interactions; quantitative proteomics.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Host-Pathogen Interactions*
  • Humans
  • Proteomics / methods*
  • Proteomics / trends
  • Virus Diseases / drug therapy
  • Virus Diseases / physiopathology*
  • Virus Diseases / virology*
  • Virus Physiological Phenomena*
  • Viruses / chemistry
  • Viruses / genetics