ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population

J Gene Med. 2017 Jan;19(1-2). doi: 10.1002/jgm.2937.

Abstract

Background: Ischemic stroke is one of the most common diseases with a high burden of neurological deficits, disability and death. Zinc finger protein 208 (ZNF208) was found to be involved in coronary heart disease, although little information is available about its association with ischemic stroke. We performed the present case-control study to clarify the association between single-nucleotide polymorphisms (SNPs) within ZNF208 and the risk of ischemic stroke in a southern Chinese Han population.

Methods: A total of 799 subjects (400 cases and 399 healthy controls) were enrolled in the present study. Five SNPs within ZNF208 gene were selected and genotyped using Sequenom MassARRY technology (Sequenom, Inc., San Diego, CA, USA). Data management and statistical analyses were conducted using Sequenom Typer, version 4.0, and a chi-squared test, as well as unconditional logistic regression.

Results: Statistical results showed that three variants were associated with the risk of ischemic stroke under allele models (rs2188971, rs2188972, rs8103163 and rs7248488). The variant rs2188972 was also associated with the risk of ischemic stroke in a recessive model after adjustment for age and sex. Haplotype analysis suggested that a significant difference existed between the Ars2188972 Trs2188971 Ars8103163 Ars7248488 haplotype and the risk of ischemic stroke, although this disappeared after adjustment for sex and age.

Conclusions: The results obtained in the present study indicate a potential association between ZNF208 variants and the risk of ischemic risk in a southern Chinese Han population.

Keywords: ZNF208; case-control study; single-nucleotide polymorphism; stroke.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Asians / genetics*
  • Case-Control Studies
  • China / epidemiology
  • DNA-Binding Proteins
  • Female
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Genotype
  • Haplotypes
  • Humans
  • Ischemia / complications*
  • Kruppel-Like Transcription Factors / genetics*
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Risk
  • Stroke / diagnosis
  • Stroke / epidemiology*
  • Stroke / etiology*
  • Transcription Factors

Substances

  • DNA-Binding Proteins
  • Kruppel-Like Transcription Factors
  • Transcription Factors
  • ZKSCAN5 protein, human