Hypocholesterolemic efficacy of royal jelly in healthy mild hypercholesterolemic adults

Pharm Biol. 2017 Dec;55(1):497-502. doi: 10.1080/13880209.2016.1253110.


Context: Royal jelly (RJ) has been reported for its health promoting factors such as antioxidant, anti-inflammatory and lipid lowering activities.

Objective: The present randomized, placebo-controlled study examines the hypolipidemic beneficial effect of RJ through evaluating anthropometric measurements, lipid profile and various hormone levels in mildly hypercholesterolemic participants.

Materials and methods: Forty subjects with mild hypercholesterolemia (180-200 mg/dL) were randomly selected and divided into two groups as experimental or placebo, who requested to intake nine capsules (350 mg/capsule) of RJ or placebo/day, respectively, for three months with one month of follow-up without any supplementation.

Results: No significant changes were noted in any of the anthropometric parameters like body weight, waist and body fat. The serum total cholesterol (TC; 207.05-183.15 mg/dL) and low-density lipoprotein cholesterol (LDL-c; 126.44-120.31 mg/dL) levels were reduced significantly (p < 0.05) after administration of RJ. However, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-c) levels were not considerably altered. Moreover, three months of RJ consumption significantly ameliorated (p < 0.05) the concentration of sex hormones like dehydroepiandrosterone sulphate (DHEA-S; 1788.09-1992.31 ng/mL). Also, intake of RJ did not elicit any hepatic or renal damage.

Discussion and conclusion: Intervention with RJ for three months considerably lowered the TC and LDL-c levels through improving the levels of DHEA-S and thus alleviates the risk of cardiovascular disease (CVD).

Keywords: Lipids; cardiovascular disease; dehydroepiandrosterone sulphate; hypercholesterolemia; royal jelly.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Anticholesteremic Agents / therapeutic use*
  • Biomarkers / blood
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood*
  • Fatty Acids / therapeutic use*
  • Female
  • Gonadal Steroid Hormones / blood
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / diagnosis
  • Hypercholesterolemia / drug therapy*
  • Male
  • Risk Factors
  • Single-Blind Method
  • Taiwan
  • Time Factors
  • Treatment Outcome
  • Triglycerides / blood


  • Anticholesteremic Agents
  • Biomarkers
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Fatty Acids
  • Gonadal Steroid Hormones
  • Triglycerides
  • royal jelly