Cognition as a treatment target in depression

Psychol Med. 2017 Apr;47(6):987-989. doi: 10.1017/S0033291716003123. Epub 2016 Dec 12.


Cognitive dysfunction in depression is associated with poorer clinical outcomes and impaired psychosocial functioning. However, most treatments for depression do not specifically target cognition. Neurocognitive deficits such as memory and concentration problems tend to persist after mood symptoms recover. Improving cognition in depression requires a better understanding of brain systems implicated in depression. A comprehensive approach is warranted for refined methods of assessing and treating cognitive dysfunction in depression.

Keywords: Cognition; depression; neuropsychological model; treatment target.

Publication types

  • Editorial

MeSH terms

  • Cognitive Dysfunction / etiology
  • Cognitive Dysfunction / therapy*
  • Depressive Disorder / complications
  • Depressive Disorder / therapy*
  • Humans