Acral manifestations of soft tissue tumors

Clin Dermatol. 2017 Jan-Feb;35(1):85-98. doi: 10.1016/j.clindermatol.2016.09.012. Epub 2016 Sep 10.


This group of biologically diverse entities is united by topographic localization to the hands and feet. Categorizing tumors by body site narrows the differential into a short list of possibilities that can facilitate accurate and rapid diagnosis. The goal of this review is to provide a practical approach to soft tissue tumors of acral locations for clinicians, pathologists, and researchers alike. What ensues in the following text is that tight coupling of the clinical picture and histopathologic findings should produce the correct diagnosis, or at least an abbreviated differential. The salient clinicopathologic, immunohistochemical, and molecular features are presented alongside current treatment recommendations for each entity.

Publication types

  • Review

MeSH terms

  • Angiofibroma / pathology*
  • Fibroma / diagnosis
  • Fibroma / pathology*
  • Fingers*
  • Giant Cell Tumor of Tendon Sheath / pathology*
  • Glomus Tumor / pathology*
  • Humans
  • Sarcoma / pathology*
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / pathology*
  • Soft Tissue Neoplasms / diagnosis
  • Soft Tissue Neoplasms / pathology*
  • Tendons
  • Toes*